Studies of the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on mammalian hepatic delta-aminolevulinic acid synthetase.
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Synergistic effect of 2,2',4,4',5,5'-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic porphyrin levels in the rat.
We studied the effect of polychlorinated biphenyls (PCBs) on hepatic porphyrin accumulation in female Sprague-Dawley rats by feeding them diets containing 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153), 2,3,3',4,4',5-hexachlorobiphenyl (PCB 156), 3,3',4,4',5-pentachlorobiphenyl (PCB 126), or combinations of the single PCB congeners with TCDD for 13 weeks...
متن کامل2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): results of a 13-week oral toxicity study in rats.
:2,3,7,8~Tetrachlorodibenzo-p-dioxin (TCDD): Results of a 13-Week Oral Toxicity Study in Rats. KOCIBA, R. J., FEELER, P. A., PARK, C. N. and GEHRING, P. J. (1975). ffoxicol. Appl. Pharmacol. , . Rats were given 2,3,7,8if tetrachlorodibenzo-p-dioxin (TCDD) at dose levels of 0, 0.001, lOffb (06ffb Iffvw \Mr* • ti.Ql, 0.1 or 1.0 pg/kg -S days/week for 13 weeks. Doses of 1.0 vpg TCDD/kg/day caused ...
متن کاملTCDD-induced changes in rat liver microsomal enzymes.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a contaminant of the herbicide 2,4,5trichlorophenoxyacetic acid (2,4,5-T), is extremely toxic (1), although the mechanism of toxicity is not known. Other papers presented at this conference cover the spectrum of environmental and health hazards of chlorinated dibenzodioxins and dibenzofurans. It should suffice to say here that these compounds are tera...
متن کاملEffect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the immune system of laboratory animals.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is one of the most toxic compounds known. TCDD and other chlorinated dibenzodioxins have been associated with occupational chloracne in workers engaged in the manufacture of technical chlorophenols and their derivatives such as the herbicide 2,4, 5-trichlorophenoxyacetic acid (2,4,5-T) (1), in lethal liver necrosis in rabbits (2), and in the chick edem...
متن کاملIncidence of jaw lesions and activity and gene expression of hepatic P4501A enzymes in mink (Mustela vison) exposed to dietary 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran.
This study assessed the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), and 2,3,7,8 tetrachlorodibenzofuran (TCDF) on the incidence of jaw lesions and on hepatic cytochrome P4501A (CYP1A) endpoints in mink (Mustela vison). Adult female mink were assigned randomly to one of 13 dietary treatments (control and four increasing doses of TCDD, PeCDF, ...
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ورودعنوان ژورنال:
- Environmental Health Perspectives
دوره 5 شماره
صفحات -
تاریخ انتشار 1973